Perricone Prescription Diet

The Perricone Prescription, an anti-aging and anti-inflammatory diet, was developed in 2002 by dermatologist and author of The Perricone Prescription, Nicholas Perricone, MD. On a mission to determine how nutrition affects the body and the aging process, he discovered that sugar causes inflammation in cells. He states that “50% of aging is a result of sugar” and claims that sugar is “as bad for your skin as sun exposure.” Dr. Perricone teaches that inflammation causes wrinkles, acne, and many other degenerative diseases.

In The Perricone Prescription, he recommends eating three meals and two snacks each day along with taking 25 supplements. He advises dieters to incorporate 20-30 minutes of physical activity as well. The daily menu on this plan includes high-quality protein, healthy fats – especially those containing omega-3 fatty acids – low-glycemic carbohydrates, spring water, and beverages high in antioxidants. Dr. Perricone also advises to eat protein before carbohydrates at each meal. Foods emphasized are naturally anti-inflammatory and help to regulate blood sugar and insulin levels.

In as little as three days on this plan, Dr. Perricone says that you can expect improved skin and damage reversal, a stronger immune system, increased bone density, improved metabolism, and a decreased risk of cancer and heart disease.

Foods to include:

  • Low-glycemic vegetables
  • Low-glycemic fruits
  • Organic animal protein
  • Wild fish
  • Some organic dairy
  • Whole grains
  • Beans
  • Nuts
  • Herbs and spices
  • Green and white teas

Foods to avoid:

  • High-glycemic vegetables
  • High-glycemic fruits
  • Duck
  • Beef
  • Hard cheeses
  • Processed carbohydrates
  • Sugar
  • Pickles
  • Soda
  • Alcohol
  • Coffee
  • Fruit juice


  • Emphasizes healthy fats, critical for brain function
  • Encourages a whole foods approach
  • May reduce the risk of cancer and other diseases


  • May be difficult to avoid coffee
  • Some dieters may need more exercise to see results
  • Some may require more structure to lose weight

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